NanoString Technologies
Spatial genomics platform maker now folded into Bruker after 2024 bankruptcy.
The NanoString name is gone, but its spatial genomics business lives on inside Bruker, still paying off the lawsuit that helped sink it.
NanoString sold gene-analysis tools for research, but filed for bankruptcy in early 2024 and was bought by larger company Bruker. The main problem is that competitor 10x Genomics won a patent lawsuit and is now collecting millions in payments through 2026, plus taking a cut of every sale Bruker makes in this area. The market itself is also getting smaller because research budgets are tighter. The one thing that could turn this around is if Bruker figures out how to grow sales again once the big settlement payments to 10x Genomics end in mid-2026, but there is no sign of that happening yet.
Whether the $68M 10x Genomics royalty settlement expires cleanly at Q2 2026. Shows if patent pressure from 10x Genomics eases or a new dispute emerges.
10x Genomics launches a next-generation spatial platform and its market share shift. Indicates whether 10x Genomics extends its lead over Bruker's spatial unit.
- 10x Genomics settlement: $68M through Q2 2026 plus royalties
- Bruker FY2025 revenue $3.436B, Q4 flat year over year
- NanoString 2023 assets $274.7M vs debts $325.3M before filing
- Ongoing $68M plus royalty payments to 10x Genomics through Q2 2026 drag on margins.
- Bruker BSI segment organic revenue declined 5.1% yoy in Q4 2025 amid academic funding cuts.
- Multi-acquisition integration risk combining NanoString, Canopy Biosciences, Bruker Spatial Genomics.
- Recurring patent litigation exposure in spatial genomics category from 10x Genomics.
| Rival | Direction | Evidence |
|---|---|---|
| 10x Genomics | losing to | Won $31M verdict Nov 2023 that helped trigger NanoString bankruptcy; $68M settlement paid through Q2 2026 |
| Vizgen | contesting | Competing MERSCOPE spatial platform; separate 10x patent suit against Vizgen dismissed Feb 2025 |
| Illumina | contesting | Broader genomics incumbent that could expand into spatial biology, per background market context |
| Thermo Fisher Scientific | contesting | Dominant life-science tools incumbent adjacent to spatial genomics category |
- Is NanoString Technologies still an independent company?
- No. NanoString filed Chapter 11 bankruptcy on February 4, 2024, and Bruker Corporation completed an asset acquisition on May 6, 2024 for about $392.6 million cash plus assumed liabilities. NanoString now operates as Bruker Spatial Biology, a division of Bruker, not a standalone public company.
- Who owns NanoString now?
- Bruker Corporation (Nasdaq: BRKR) owns NanoString's former assets after completing a $392.6 million asset purchase on May 6, 2024, following NanoString's Chapter 11 filing. The business runs as Bruker Spatial Biology alongside Canopy Biosciences and Bruker Spatial Genomics.
- Who is NanoString's biggest competitor?
- 10x Genomics. It won a $31 million patent jury verdict against NanoString in November 2023, a factor in NanoString's February 2024 bankruptcy, and in May 2025 settled with new owner Bruker for $68 million in installments plus ongoing royalties on spatial-biology sales.
- Did NanoString have layoffs before its bankruptcy?
- Yes. NanoString cut 20% of its workforce in October 2023, months before withdrawing FY2023 guidance, seeing its stock drop more than 50% in a single day, and filing Chapter 11 bankruptcy on February 4, 2024.
- Could AI replace NanoString's spatial biology products?
- AI is being added to the downstream AtoMx informatics layer (AI cell segmentation models shown April 2025, an LLM-based Spatial Discovery query tool shown April 2026), but the underlying instruments, reagent chemistry, and imaging IP remain the moat AI software alone cannot replicate as of April 2026.
- Is Bruker Spatial Biology (NanoString's successor) profitable?
- Standalone financials are not disclosed; NanoString's business is folded into Bruker's BSI segment, which posted organic revenue down 5.1% year over year in Q4 2025 while Bruker overall reported $3.436 billion FY2025 revenue and called it a difficult year, per its February 11, 2026 results release.
- 2026-04-16AACR 2026: Bruker Spatial Biology launches cross-platform GeoMx-to-CellScape workflows
- 2026-02-22AGBT 2026: CellScape XR spatial proteomics platform launched, Glasgow collaboration announced
- 2026-02-12Bruker reports FY2025 results, BSI segment organic revenue down 5.1% yoy
- 2025-05-18Bruker settles 10x Genomics patent suits for $68M installments plus royalties
- 2025-04-24AACR 2025: CosMx 2.0 and AI cell segmentation models launched on AtoMx
- 2025-02-20AGBT 2025: PaintScape, CosMx WTX, PowerOMX launched
- 2024-05-06Bruker completes $392.6M asset acquisition of NanoString
- 2024-04-17Bruker signs asset purchase agreement for NanoString business
- 2024-02-04NanoString files Chapter 11 bankruptcy in Delaware
- 2023-1110x Genomics wins $31M patent jury verdict against NanoString
- NanoString Technologies Files for Chapter 11 Bankruptcy (2024-02-05)
- Bruker Completes Asset Acquisition of NanoString Business (2024-05-06)
- NanoString Technologies to Be Acquired by Bruker Corporation (2024-04-17)
- 10x Settles Bruker, Vizgen Patent Lawsuits (2025-05-18)
- NanoString Technologies -> History (2026-07-24)
- Bruker Reports Fourth Quarter and Full Year 2025 Financial Results (2026-02-11)
- Bruker details 2025 segments, risks and backlog (2026-02-27)
- Bruker Spatial Biology Pushes Boundaries in Spatial Biology and Multiomics at AACR 2025 (2025-04-25)
- Bruker Spatial Biology Pushes Boundaries in Spatial Biology and Multiomics at AACR 2025 (2025-04-24)
- Bruker Announces Major Advancements at AGBT to Enable Complete High Fidelity Spatial Biology Across the Biolog (2026-02-22)
- Bruker Spatial Biology to Announce Groundbreaking Advances at AGBT 2025 (2025-02-20)
- AACR2026 Spatial Discovery poster (2026-04)